A mild association has been reported between CSF markers of neuronal injury (14-3-3 protein and NfL) and plasmatic t-PrP, suggesting that plasma t-PrP might be regarded as a biomarker of neurodegeneration, in contrast to CSF t-PrP, which probably reflects pathogenic PrP aggregation occurring in prion disease patients. Here, PRNP is linked to prion disease.