An interesting target for preventing IR and T2DM seems to be phosphatidylinositol 4-phosphate 5-kinase type I c, which is known for regulating focal adhesion formation, invasion, and cell migration signal transduction cascades with the crosstalk with intercellular adhesion molecule-1 (ICAM-1) and mTORC1-induced upregulation of the glycolytic pathway, and also favors the differentiation of specific inflammatory Th cell subsets [95,96]. Here, ICAM1 is linked to type 2 diabetes mellitus.