On the basis of the results obtained in this study, we established that current frequencies of the detrimental G allele of the SNP in the upstream of the bovine FOXP3 gene are particularly high in local populations of IM cows compared with those of three other assessed breeds, among which, G allele frequencies are low in KH and JB cows, and moderate in HF dairy cows. This evidence concerns the gene FOXP3 and hydrops fetalis.