TP53 and cancer: As Zhang et al. reported evidence that the LINC-RoR is a potent negative regulator of p53 translation through direct interaction with the heterogeneous nuclear ribonucleoprotein I (hnRNP I) with subsequent inhibition of p53-mediated cell cycle arrest and apoptosis [46], it can be speculated that in the case of carriers of the ancestral allele (non-pathological one) that is not associated with dysregulated ROR expression, the p53 regulatory mechanisms on the cell apoptosis will be issued, improving the cancer cell outcome.