As Zhang et al. reported evidence that the LINC-RoR is a potent negative regulator of p53 translation through direct interaction with the heterogeneous nuclear ribonucleoprotein I (hnRNP I) with subsequent inhibition of p53-mediated cell cycle arrest and apoptosis [46], it can be speculated that in the case of carriers of the ancestral allele (non-pathological one) that is not associated with dysregulated ROR expression, the p53 regulatory mechanisms on the cell apoptosis will be issued, improving the cancer cell outcome. The gene discussed is PTBP1; the disease is cancer.