As concerns the lipid lowering pharmacological strategy, high-intensity statin is the cornerstone of lipid lowering therapy (LLT) in FH subjects and the addition of the PCSK9 inhibitor (PCSK9-i) effectively reduces the LDL-C amount; thus, the administration of PCSK9-i is needed especially in subjects at higher cardiovascular risk as FH [24]. Here, PCSK9 is linked to familial hyperaldosteronism.