PCSK9 and atherosclerosis: Indeed, the finding that a PWV decrease was less marked in patients with a wider PCSK9 plasma level increase appears to support the hypothesis that PCSK9 could be an interesting cardiovascular biomarker of the mechanical vascular homeostasis through lipid and non-lipid pathways and it could be able to identify subjects at high ASCVD risk with a limited LDL-C lowering benefit after high intensity statin.