NFE2L2 and viral load: Reduced expression of selenoproteins as a result of low/sub-optimal selenium status could alter the molecular pathways involved in stress responses and contribute to an aggressive pro-inflammatory environment due to an imbalance between NF-κB and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling (Figure 1), which may lead to poorer viral disease prognosis [85].