In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs. A allele: p = 0.017, OR = 12.064, 95% CI: 1.570–92.688), dominant model (GA + AA vs. GG: p = 0.016, OR = 0.08, 95% CI: 0.010–0.620), and codominant model (GA vs. GG: p = 0.016, OR = 1.026, 95% CI: 0.821–1.282). Here, TLR2 is linked to periodontitis.