Nutlins and their analogs (such as MI-43, MI-63, and MI-319) synergize with genotoxic drugs such as 5-FU, doxorubicin, etoposide, and cisplatin in multiple tumors carrying wild-type p53 such as hematological malignancies, lymphoma, neuroblastoma, hepatocellular carcinoma, lung cancer, and pancreatic cancer. The gene discussed is TP53; the disease is pancreatic neoplasm.