Previous studies have shown a relationship between leptin and glucose regulation in fishes; where treatment with exogenous leptin induces hyperglycemia in goldfish, (C. auratus, [53]), rainbow trout (O. mykiss, [5]), and tilapia (Oreochromis mossambicus, [6]; Oreochromis niloticus, [54]). This evidence concerns the gene LEP and Hyperglycemia.