IRS1 and lung carcinoma: For instance, RP11-817O13.6 increased first (0.63 μmol/L) and then decreased at the higher dose (10 μmol/L), suggesting that the ncRNA profiling may change according to the amount, the time of exposure, and even the cell type, as seen in BEAS-2B-Cr (1 μM) cells where miR-143 expression levels were much higher than in the lung cancer cells A549 and H2195, that further lead to Cr (VI)-induced cell malignant transformation via upregulation of insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor substrate-1 (IRS1) expression [226].