A recent study evaluated the utility of Rd in gastrointestinal mucosal regeneration and clarified that Rd could stimulate the proliferation and differentiation of endogenous intestinal stem cells and improve recovery of intestinal function in a rat model of inflammatory bowel disease (IBD) by increasing the expression levels of Bmi, CDX-2, and Msi-1 [62]. Here, MSI1 is linked to inflammatory bowel disease.