In contrast, pre-treating C57BL/6 mice with Nω-nitro-L-arginine methyl ester (a NO synthase inhibitor) followed by Ang II and β-aminopropionitrile (BAPN) infusion augmented aortic dissection and aneurysm rupture compared to Ang II and BAPN infusion alone [98]. Here, AGT is linked to aneurysm.