Intriguingly, other mutations contributing to familial PD and DLB are found within endosomal/lysosomal machinery related genes, such as leucine rich repeat kinase 2 (LRRK2) and ATP13A2, or in mitochondrial-related genes, such as protein deglycase DJ-1, PTEN-induced kinase 1 (PINK1), and parkin (Table 1). The gene discussed is LRRK2; the disease is Lewy body dementia.