mRNA levels of AChRα—whose expression is induced with denervation or synaptic dysfunction [43]—were progressively increased from 6 months of age reaching a 4-fold induction in HE mice compared to nTg mice, while mRNA levels of AChRε and Musk were only increased at 18–24 months by ~3-folds, and AChRγ mRNA levels were decreased by 30%. This evidence concerns the gene CHRNE and hereditary elliptocytosis.