In our opinion, it is not surprising that the systemic levels of endocan and p14 endocan fragment show no strong correlation in acute leukemia patients (Table S1), because a similar observation with lack of correlation between these two endocan forms has also been described for sepsis patients [30] and their prognostic impact in intensive care patients with hematological malignancies also seems to differ [32]. Here, ESM1 is linked to acute leukemia.