However, the general increase and wide variation in serum endocan levels in acute leukemia at the time of diagnosis [3] together with the importance of angiogenesis for leukemogenesis/chemosensitivity and angiogenesis [10,11,12,15,58,59] suggest that future studies should investigate whether systemic endocan levels have a prognostic impact also in acute leukemias and not only in solid tumors. The gene discussed is ESM1; the disease is acute leukemia.