JPH2 and heart disorder: Nevertheless, while JPH degradation results in the modification of the geometry of triads and diads, leading to ECC alterations, the N-terminal fragment of JPH2 generated by calpain digestion in stressed cardiac muscle was found to translocate to the cell nucleus, where it acts as a transcriptional regulator mitigating the hypertrophic response to cardiac disease [101,102,103,104,105].