In the heart, remodeling and loss of TT in chronic heart failure, in aging or in cardiomyopathies correlate with downregulation of JPH2 protein expression and/or loss of JPH2 localization at TT; in addition, mutations in JPH2 are linked to the development of cardiomyopathies [95,96,97,98,99,100]. The gene discussed is JPH2; the disease is cardiomyopathy.