KCNK3 and idiopathic pulmonary arterial hypertension: Importantly, PAH patients with KCNK3 mutations were younger at diagnosis than iPAH patients and were more severe than iPAH patients, as indicated by a higher mean pulmonary arterial pressure (mPAP) (76 mmHg compared to 56.4 mmHg) [160], suggesting the crucial role played by KCNK3/TASK1 in PAH pathogenesis.