Specifically, with CSI, diameter ≥ 2.9 cm, and Ki-67 > 3 as the cutoff value, the specificity of predicting persistent hypersecretion syndrome and residual adenoma was 98.7% (odds ratio, 8.6; confidence interval, 3.0–24.7), which showed an excellent predictive effect. The gene discussed is MKI67; the disease is adenoma.