In MM, microRNA-15a/-16 regulates proliferation and growth of MM cells in vitro and in vivo by inhibiting AKT serine/threonine-protein-kinase (AKT3), ribosomal-protein-S6, MAP-kinases and NF-κB-activator MAP3KIP3 [153]. This evidence concerns the gene AKT1 and Miyoshi myopathy.