Clonal diversity has been evidenced by showing multiple unrelated clonal Ig gene rearrangements in the same cHL cases (such as combined unproductive IGHD-IGHJ gene rearrangements and productive IGHV-IGHD-IGHJ gene rearrangements) or even involving both IGH and IGK genes [19]. This evidence concerns the gene IGHD and classic Hodgkin lymphoma.