Song et al. demonstrated that the expression of CADM4 is down-regulated in gastric cancer tissues and cell lines, and that down-regulation of CADM4 in patients without lymph node metastasis is significantly associated with the degree of cell differentiation, depth of tumor invasion, lymph node metastasis, and TNM stage [19]. Here, CADM4 is linked to metastatic malignant neoplasm in the lymph nodes.