Of note, it has been reported that between 40% and 60% of MM cases present mutation in exon 15 of the v-RAF murine sarcoma viral oncogene homolog B (BRAF), leading to valine (V) changing into glutamic acid (E) as a result of substitution at this exon (GTG > GAG) in the second placement of codon 600 (V600E) of BRAF kinase [7], namely BRAF V600E mutation. This evidence concerns the gene BRAF and Miyoshi myopathy.