FGFR2 and hilar cholangiocarcinoma: Meanwhile, Maruki et al. revealed FGFR2–FISH (fluorescent in situ hybridization) positive (FGFR2 rearrangement) rate confirmed by RNA sequencing, 5.4% (23/423; 7.4%, ICC; 3.6%, PCC), in a large Japanese cohort including 272 patients with ICC, 83 patients with perihilar cholangiocarcinoma (PCC), and 68 other BTC patients, using 125 surgical, 177 percutaneous/27 forceps biopsy, and 26 EUS-FNA specimens [52].