NLR demonstrated a high impact on the COVID-19 mortality (HR 1.317; 95%CI 1.004–1.728; p < 0.05), whereas CRP and SII showed no effect (HR 1.000; 95%CI 1.000–1.004; p = 0.085 and HR 1.078; 95%CI 0.865–1.344; p = 0.503, respectively). The gene discussed is CRP; the disease is COVID-19.