A total of 71.8% of heart failure patients in the COVID-19 group had CRP values outside the normal range, compared with only 23.3% in patients without COVID-19 (p-value < 0.001); IL-6 in the disease group had a median of 48 pg/mL, compared with 15 pg/mL in the control group (p-value < 0.001); 53.2% of heart failure patients with COVID-19 had TNF-α values outside the normal range, while it was 15.7% outside normality in the control group (p-value < 0.001). This evidence concerns the gene TNF and heart failure.