In this scenario, ETS homologous factor (EHF), a molecule of the epithelium-specific subfamily (E26 transformation-specific (ETS) transcription factor family), seems to be involved in the regulation of the EMT by activating the ZEB1 promoters [19,20]; however, the involvement of EHF in cancer occurrence and progression is a very debated issue in the oncological research. This evidence concerns the gene ZEB1 and cancer.