Table S2 shows the gene effect scores. Knockouts/knockdowns of several target genes with scores below −0.5 (an accepted cutoff value) can be related to tumor cell viability (Table S2): TBXAS1 (gallbladder adenocarcinoma, OCUG1 cell culture), PTGDR (lung cancer, CORL279), PTGER4 (lymphoma, C8166) and PTGES3 (brain cancer, ONS76). Incidentally, PTGES3, being the most common DEG in various tumors (Figure 3), tends to be an essential gene in tumor cell lines (Table S2). This evidence concerns the gene PTGER4 and lung cancer.