Most of the transcriptomic signatures (without subgroup analysis) still show acceptable tumor specificity with the exception of the signature containing PTGDS, CBR3, PTGIR, PTGFR, PTGDR2, and PTGER3 genes in HNSC tumor, which is similar to other tumors (BRCA, CESC, LUAD, SARC, and UCES). The gene discussed is CBR3; the disease is neoplasm.