We found that the expression of N-WASP was reduced in SCC patient samples compared to matched perilesional controls (Figure 1A), and the levels of N-WASP protein and transcripts were reduced in the SCC skin cell line HSC-5 compared to non-tumorigenic cell line HaCaT (Figure 1B–D), suggesting that reduced N-WASP levels in skin cells may promote skin carcinogenesis. This evidence concerns the gene WASL and neoplasm.