SAMD1 and atherosclerosis: Indeed, SAMD1 has been proposed to play a role in atherosclerosis [12], was identified in a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) screen to be essential for the growth of K562 cancer cells [13], and via a GWAS study, the nonsynonymous variant E338D of SAMD1 was linked to the immune response after malaria infection [14].