Significant upregulation of SAMD1 occurs in cholangiocarcinoma (CHOL), diffuse large B-cell lymphoma (DLBC), head and neck squamous cell carcinoma (HNSC), brain lower-grade glioma (LGG), liver hepatocellular carcinoma (LIHC), ovarian serous cystadenocarcinoma (OV), pancreatic adenocarcinoma (PAAD), sarcoma (SARC), and thymoma (THYM). This evidence concerns the gene SAMD1 and head and neck squamous cell carcinoma.