On the other hand, genome-scale CRISPR-Cas9 loss-of-function screens (CERES [11]) determined 176 essential RBPs (Figure 6A), being RAN, HSPE1, SNRNP200, SNRPD1, SARS, EEF2, RPL37, CCT3, KPNB1, and RPL23 (mean dependency scores ranging from −1.5 to −1.8) the top ten essential RBPs for tumor survival (Table S9). The gene discussed is KPNB1; the disease is neoplasm.