ISY1 and breast cancer: Thus, we identified essential RBPs for each BC subtype: seven LumA (HSPD1, UBE2M, SART3, USP36, GTPBP4, DHX33, and UPF1), five LumB (RPS21, GNL3L, ZNF207, AQR, and RPL17-C18orf32), seven Her2 (DDX39B, NMT1, ISY1, DARS, HEATR1, MAT2A, and SYF2), and nine Basal (EIF3C, UTP20, TXN, NOP58, ALDOA, CCT2, NOP2, DDX54, and PRMT1) (Figure 6B).