The genome-scale RNAi loss-of-function screens (DEMETER2 [12,13]) identified 90 essential RBPs (Figure 6A), being SNRPD1, SF3B1, SF3B2, RPL5, ARCN1, EIF3B, RAN, COPB1, RPL14, and VCP (mean dependency scores ranging from −1.3 to −1.5) the top ten essential RBPs for BC survival (Table S8). Here, SF3B1 is linked to breast cancer.