With the IL6 expression by pancreatic stellate cell (PSC) in mind, the authors tested the effect of an IL6 neutralizing antibody on subcutaneous tumors of MT5 and Panc02 (mouse pancreatic cancer cell lines), and demonstrated that while IL6 antibody itself had a minor effect, its combination benefited anti-PD-L1 efficiency. The gene discussed is CD274; the disease is pancreatic neoplasm.