CD8A and pancreatic neoplasm: Although the advantage of stroma targeting in pancreatic cancer is still under debate [52,53], the works from Zhao et al. [119] and Zhou et al. [120] supported the notion that the entry of CD8+ T cells has a higher benefit than the depletion of fibroblasts in this process, as CD8+ T cell infiltration is the main determinant of treatment efficiency with or without fibroblast alteration.