The approach uncovered candidate PE, HexCer, and TG pathways that might be amenable to therapeutic interventions supported by experimental studies showing therapeutic anti-inflammatory effects of the endocannabinoid, PEA in stroke or brain trauma [20,21,22,55], of fatty acid amide hydrolase inhibitors [17,19] and of GM1 gangliosides in TBI mouse models [56,57,58]. Here, FAAH is linked to brain injury.