The pediatric mesangial glomerulosclerosis (in DDS/Frasier syndrome) can be explained through later-stage developmental issues regarding embryological podocyte cell line differentiation and metabolic homeostasis in adult life, with multiple investigations making it abundantly clear that WT1 is essential for both of these processes [29,82,84,91,96]. The gene discussed is WT1; the disease is Frasier syndrome.