WT1 and congenital diaphragmatic hernia: WT1 null mice will be unable to develop kidneys and gonads; will exhibit congenital diaphragmatic hernia; and will die in utero, on average, at ~13.5 embryonic days, presumably due to cardiac problems [79], while also manifesting hypoplastic lungs, splenic agenesis [80] and adrenal gland agenesis [81,82].