Even more compelling is the fact that, following cardiac ischemia in adults, WT1 transcription reactivation occurs in the mature epicardium, determining epicardial cell proliferation and spawning a new wave of progenitors which have the potential to induce coronary neoangiogenesis and, albeit controversially, cellular repopulation of the myocardium [110]. This evidence concerns the gene WT1 and myocardial ischemia.