A locally advanced tumor stage more than ≥ pT3, LN involvement and LVI (only for patients with MPUC, all p < 0.05), and positive PD-L1 in TICs were also significantly associated with an increased risk of tumor recurrence both in patients with MPUC (hazard ratio (HR) = 1.85; 95% confidence interval (CI): 1.323–2.672; p = 0.017), and in patients with MPUC (HR = 1.58; 95% CI: 1.162–2.780; p = 0.032). Here, CD274 is linked to neoplasm.