PNPLA3 and metabolic dysfunction-associated steatohepatitis: Currently, a clinical study of an antisense medicine AZD2693, which was designed to inhibit the production of PNPLA3 protein, is ongoing to investigate its effects on patients with NASH, fibrosis stage 0 to 3, who are homozygous for the PNPLA3 148M risk allele (ClinicalTrials.gov identifier: NCT04483947).