In 2008, for the first time, genome-wide association studies reported the I148M single nucleotide polymorphism (SNP; rs738409, C > G) in the patatin-like phospholipase domain containing protein 3 (PNPLA3), which is a susceptibility gene involved in the development of NAFLD [15]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.