Similarly, Jiang et al. suggested that another microRNA, MiR-577, also had tumor suppressor properties in 5-FU-resistant SW480 colon cancer cells through direct MiR-577 and Hsp27 interaction and subsequent induction of G0/G1 cell cycle arrest, yet the exact molecular mechanisms behind this cell cycle arrest were not described. Here, HSPB1 is linked to colonic neoplasm.