Fang et al., in their in vitro study, using pancreatic ductal adenocarcinoma cell lines, highlighted the Hsp27-induced modulation of the β-catenin/MMP3 signaling cascade [54], a crucial pathway of the EMT, while Zhu et al. proposed that Hsp27 promotes EMT via upregulation of the NF-kB signaling pathway [55]. Here, HSPB1 is linked to pancreatic ductal adenocarcinoma.