Lin et al. described that CD133+ CSCs from four different cancer types (colorectal, brain, lung, and oral cancer) managed to survive hypoxia and serum depletion-mediated apoptosis through upregulation of the p38 MAPK/MAPKAPK2 pathway, phosphorylation of Hsp27 and inhibition of caspase-mediated apoptosis [59]. The gene discussed is HSPB1; the disease is cancer.