It was reported that the downregulation of Hsp27 by small interfering RNAs (siRNAs) and the consequent inhibition of its chaperoning activity in oxidative stress seem to enhance the sensitivity of paclitaxel in human ovarian cancer cells (HO8910) as well as in bladder cancer cells by increasing apoptosis rate [128,129]. The gene discussed is HSPB1; the disease is urinary bladder cancer.