Other molecules that decreased the expression of HSP27 in gemcitabine resistance pancreatic cancer cells included the basidiomycete mushroom active hexose-correlated compound (AHCC) [101], the N-formyl-3,4-methylenedioxy-benzylidene-γbutyrolactam (KNK437) [109], and the extract of Tripterygium wilfordii, a traditional Chinese herb, triptolide [110]. This evidence concerns the gene HSPB1 and familial pancreatic carcinoma.