Indeed, the bioinformatics analysis predicted that miRs altered in RA are involved in the negative regulation of different types of collages (COL1A1, COL1A2, COL3A1, COL5A1, and COL27A1) and integrins (ITGA8, ITGA8, ITGA8, ITGA8, and ITGA8) (Figure 2A). This evidence concerns the gene COL1A1 and rheumatoid arthritis.