The APO E parameter (dyslipidemia-atherosclerosis) in the E3/E3 allele demonstrated indirect dependency for eNOS G894T=homozygote (endothelial ischemia) as well as for EPCR A4600G=homozygote (endothelial receptor thromboembolism), factor XIII=homozygote (thrombogenesis and thrombolysis), HPA1 a/b GPIIIa L33P=a/b (dysfunction of platelet aggregation and adhesion) and LTA C804A=homozygote (thrombogenic endothelial immunocompetence). This evidence concerns the gene HPSE and metabolic syndrome.