In fact, a recent review on humanin by Hazafa et al. [56] reinforced the importance of this mitochondrial-derived peptide and its isoforms in cytoprotection through the regulation of different mechanisms, including mitochondrial pathways, with a potential influence on the development and treatment of multifactorial diseases related to oxidative stress and apoptosis, which comprise neurodegenerative diseases such as AD. The gene discussed is MT-RNR2; the disease is Alzheimer disease.