Regarding the epistatic interactions with MT-ND5(13135), there was no statistical significance in the comparison of carriers of MT-ND2(5633) and MT-ND5(13135) (Figure 3H), but we found higher levels of CSF TAU in healthy and AD individuals with the TT/GG genotype for MT-COX1(7476) and MT-ND5(13135) in comparison to the analyzed pair for these variants (Figure 3I). The gene discussed is MT-ND5; the disease is Alzheimer disease.