Moreover, a common CB2 functional variant, Q63R, causing CB2 reduced function, has been associated with several inflammatory and autoimmune diseases [31,32,33] In this study, we isolated macrophages from the peripheral blood of CD patients to investigate CB2 expression and macrophage phenotype and to evaluate the effects of CB2 pharmacological modulation on CD macrophage polarization. The gene discussed is CNR2; the disease is Cowden disease.