Despite alterations in the protein levels of mitochondrial ETC subunits, as well as functional changes, not being observed in our L1 mouse model, proteomic and functional analyses carried out on other AD animal models, such as 3xTg-AD, have reported changes in the subunits of the ETC (such as the components of mitochondrial complex I and complex IV), mitochondrial respiration [48], and complex V subunit ATP5H [70]. The gene discussed is ATP5PD; the disease is Alzheimer disease.