Our group recently showed in a large-scale proteomics study performed on another mouse model of tauopathy—line 66 (L66), expressing the longest full-length human tau isoform carrying a P301S mutation—that out of 2000 spots from 2-DE analysed by MS, 3.5% were dysregulated in L66, with 22% of those belonging to metabolic pathways and regulated by HMTM [78]. Here, MAPT is linked to tauopathy.