As mGluR1 and mGluR5 are widely expressed in the basal ganglia structures, especially at postsynaptic sites [90], and a high expression of mGluR1 receptors can be found in the globus pallidum (GP), substantia nigra pars reticulata (SNr), and striatum, therefore they might be involved in PD pathogenesis. The gene discussed is GRM5; the disease is Parkinson disease.