HMGB1 and neoplasm: In contrast, cells treated with NIR-PIT release cellular contents including both tumor neoantigens and danger signals, such as calreticulin (CRT), adenosine triphosphate (ATP), high-mobility group box 1 (HMGB1), heat shock protein (Hsp) 70, and Hsp 90, which activate immature dendritic cells (DCs) and stimulate the presentation of tumor antigens to T cells [6,10].