This is in line with previous studies investigating the transcriptional profile of murine microglia in EAE and human microglia derived from MS samples describing the emergence of microglial subclusters with downregulated expression of microglia signature genes such as the purinergic receptor P2Y12 (P2ry12), G-protein coupled receptor 34 (Gpr34), Sialic acid binding Ig-like lectin H (Siglech) and Spalt-like transcription factor 1 (Sall1) [28,42]. Here, GPR34 is linked to myeloid sarcoma.