One of the cornerstones of SARS-CoV-2 pneumonia therapy is represented by high dosage steroids (e.g., dexamethasone 6 mg daily) [42], which is known to cause gonadotropin hormone-releasing hormone (GnRH) dysregulation and subsequently secondary hypogonadism [43]. Here, GNRH1 is linked to hypogonadotropic hypogonadism.