Among the 28 patients with C9ORF72 expansion and family history, 12 had a family history of both ALS and FTD, nine had a family history of ALS and seven of FTD; all eight fALS patients with an SOD1 mutation had a family history of ALS, whereas no cases with a family history of FTD were detected. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.