Differences in the levels of 1,25(OH)2D3 between patients with active TB and individuals with LTBI could perhaps explain the enhanced expression of IL-15 observed in individuals with LTBI; and the impossibility of carrying out the culture PBMC under hypoxic conditions using a hypoxia chamber in this study did not allow for conclusions regarding the main environments in which HIF-1α was originally expressed. This evidence concerns the gene HIF1A and tuberculosis.