Furthermore, it is unlikely that the lack of Cbl in the MS SC is responsible for any aberrant regulation of gene expression and/or epigenetic changes occurring in remyelinating ODCs [111,360,361,362,363,364,365], because DNA hypomethylation of the white matter from MS brains is due to increased DNA demethylation activity rather than a decrease in methyltransferase activity [361,362,364,365]. This evidence concerns the gene CBL and myeloid sarcoma.