NSCs play a major role in relation to CNS demyelinating insults, as they can be committed to a neuronal or glial cell lineage by external factors (e.g., EGF and/or other neurotrophic growth factors [140,141,142]); therefore, NSCs affect the recovery capacity of the CNS in MS, and after chemically- and/or virally-induced demyelination [143,144]. This evidence concerns the gene EGF and myeloid sarcoma.