Moreover, we can reasonably exclude that this dichotomy between CSF Cbl levels and those of SC is due to reduced Cbl transport in MS CSF, as there were no changes in CSF levels of holotranscobalamin (which binds biologically active Cbl) in any of our MS patients, regardless of their clinical course, in comparison with the controls [359]. This evidence concerns the gene CBL and myeloid sarcoma.