Some main findings supporting a non-autoimmune-mediated pathogenesis of MS (e.g., abnormalities in the CNS myelin structure and in the OPC→ODC lineage maturation, CNS glutamate excitotoxicity, abnormal CNS levels of glial fibrillary acidic protein (GFAP), inhibitory molecules in the CNS ECM, and abnormal levels of CNS PDGF and EGF) have been previously discussed in a recent review by this author [288]. Here, GFAP is linked to myeloid sarcoma.