Given that Cbl→EGF→ PrPcs are an interconnected sequence of molecules in CNS [48], this review is focused on the effects of EGF, Cbl, and PrPCs on the main CNS cells involved directly or indirectly in myelinogenesis, and the derangements of these molecules in MS and MS-like experimental models. This evidence concerns the gene EGF and myeloid sarcoma.