Indeed, inhibition of HK2 by ketoconazole and posaconazole revealed an inhibitory effect on GBM both in vitro and in vivo [115]; activation of PINK1 suppresses ROS and tumor growth through FOXO3a and reduces in vivo glioblastoma growth in orthotopic mouse xenograft models [116]. Here, FOXO3 is linked to glioblastoma.