In hypoxic pseudopalisading GBM cells, proinflammatory-gene expressions, such as C-X-C chemokine receptor type 4 (CXCR4), are upregulated by HERs-gene transcription, stimulating migration but also the proliferation of endothelial cells close to necrotic or hypoxic areas [95]. The gene discussed is CXCR4; the disease is glioblastoma.