MMP2 and glioblastoma: Immunosuppressive TAMs support GBM-invasion-expressing MMP-2 and MMP-9, which are also involved in angiogenesis, apoptosis, and cell proliferation; these hallmarks are fostered by the production of EGF, VEGF, and TGF-β1 by TAMs, which induce EMT in GBM cells [125].