Immunosuppressive TAMs have protumoral properties, such as promoting vascularization, invasion, proliferation and immunosuppression [129]; TGF-β and IL-10 released by M2-like macrophages and by GBM cells stimulate capillary formation and angiogenesis interacting with endothelial cells and macrophages via αvβ3 integrin expression and SRC-PI3K-YAP signaling [130]. This evidence concerns the gene TGFB1 and glioblastoma.