In particular, during the transition from the first vascular phase, in which cancer cells are supported by native blood vessels, to the neovascularization phase, a vascular-cell apoptotic program activated by Ang-2 expression in GBM cells, followed by vascular involution and finally to downstream effects stimulating the neoangiogenesis by VEGFR transcription [65,66]. This evidence concerns the gene ANGPT2 and glioblastoma.