In our study, we found that poor prognosis, including PFS and OS, were mentioned in patients with well-known poor prognostic factors, such as advanced T or N status, high tumor grade, negative HPV status, etc. In addition, patients without VEGF or SDF-1α decrease after TPF treatment, or higher post-TPF VEGF or SDF-1α values were also mentioned to have a worse prognosis, whether in the univariate or multivariate analysis. This evidence concerns the gene VEGFA and neoplasm.