Our study showed that SDF-1α and VEGF play crucial roles in HNSCC disease progression and that decreased SDF-1α and VEGF levels after TPF treatment, and lower post-TPF SDF-1α and VEGF values are independent prognostic factors for superior prognosis in patients with HNSCC who received induction chemotherapy with TPF followed by CRT. Here, VEGFA is linked to head and neck squamous cell carcinoma.