With respect to the post-TPF SDF-1α and VEGF values, the 77 HNSCC patients were divided into three groups, including group 1: patients with both post-TPF VEGF ≥ 150 pg/mL and SDF-1α ≥ 1500 pg/mL, group 2: did not meet the criteria of group 1 and group 3, and group 3: patients without both post-TPF VEGF ≥ 150 pg/mL and SDF-1α ≥ 1500 pg/mL. Here, CXCL12 is linked to head and neck squamous cell carcinoma.