In the current study, patients with decreased SDF-1α and VEGF levels after TPF treatment and lower post-TPF SDF-1α and VEGF values were noted to have superior PFS and OS compared to those who did not, suggesting that SDF-1α and VEGF are both independent prognostic factors in patients with HNSCC who underwent induction chemotherapy with TPF. Here, CXCL12 is linked to head and neck squamous cell carcinoma.