In the analysis of the kinetic change of VEGF and SDF-1α, the 77 HNSCC patients were divided into three groups, including group 1: patients without both VEGF and SDF-1α decreased after TPF, group 2: did not meet the criteria of group 1 and group 3, and group 3: patients with both VEGF and SDF-1α decreased after TPF. Here, CXCL12 is linked to head and neck squamous cell carcinoma.