Our study showed that SDF-1α and VEGF play crucial roles in HNSCC disease progression and that decreased SDF-1α and VEGF levels after TPF treatment, and lower post-TPF SDF-1α and VEGF values are independent prognostic factors for superior prognosis in patients with HNSCC who received induction chemotherapy with TPF followed by CRT. The gene discussed is CXCL12; the disease is head and neck squamous cell carcinoma.